poloxamer 188 การใช้

Another, more promising approach, is the coating of polyalkylcyanoacrylate or poly-lactic-co-glycolic acid ( PLGA ) nanoparticles with polysorbate 80 or poloxamer 188.
Surfactants such as polysorbate 80, 20, 40, 60, and poloxamer 188, demonstrated positive drug delivery through the blood brain barrier, whereas other surfactants did not yield the same results.
Dr . R . Martin Emanuele, the company's vice president for research, said Flocor was a highly purified version of poloxamer 188, an emulsifying chemical used in food products and other drugs to change the surface tension of oil-water mixtures.
Wang et al . reported that aqueous solutions of poloxamer 188 ( Pluronic?F-68 ) and poloxamer 407 ( Pluronic?F-127 ) sonicated in the presence or absence of multi-walled carbon nanotubes ( MWNTs ) can became highly toxic to cultured cells.
He developed a skin wound cleanser safe enough to be poured into the patient s eye without toxic effects, a solution of poloxamer 188 that has now been approved for use by the Food and Drug Administration ( FDA ) and is now marketed as Shur-Clens by ConvaTec ( Skillman, New Jersey ).